Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat

PERAN PENGETAHUAN DAN SIKAP REMAJA PEREMPUAN DALAM PRAKTIK PENCEGAHAN ANEMIA DI GONDANGREJO, KARANGANYAR

Wahyu Ratri Sukmaningsih — 2025-06-30

One of the public health problems is anemia in adolescent girls, which has an impact on growth, development, and productivity. It is expected that good knowledge and attitudes can help carry out effective anemia prevention measures. This study aims to study how the knowledge and attitudes of adolescent girls in Gondangrejo District, Karanganyar, contribute to anemia prevention practices.

This study employed a quantitative observational analytic method with a cross-sectional design involving 30 adolescent girls selected through purposive sampling. Data were collected using a structured questionnaire that had been tested for validity and reliability. Data analysis was conducted using univariate and bivariate methods with the Chi-square test.

The majority of respondents demonstrated positive levels of knowledge and attitudes towards anemia prevention. There was a significant relationship between knowledge level (p = 0,002) and attitude (p = 0,001) with anemia prevention practices. Knowledge and attitude play an important role in promoting anemia prevention practices among adolescent girls. Continuous educational efforts need to be enhanced to optimize anemia prevention within this population.

Keywords: Anemia, Knowledge, Practice, Adolescent Girls, Attitude

EVALUASI WAKTU TUNGGU PELAYANAN RESEP OBAT PASIEN RAWAT JALAN DI PUSKESMAS PEDAN KABUPATEN KLATEN

Riyan setiyanto — 2025-06-30

Pharmaceutical services at community health center are the final stage of the servive process which is a service for taking medicines with the provision that the waiting time for prescription services for compounded medicines ≤60 minutes and prescriptions for non-compounded medicines ≤30 minutes. Waiting time prescription services has an important role in health services, because service time is factor for measuring the effectiveness of an organization which consists of accuracy and speed of time. This study aims to determine the average waiting time for prescription drug services at Pedan Health Center, Klaten Regency. This type of research is non-experimental quantitative descriptive with a sampling method, namely incidental sampling carried out by chance using a form for waiting time for prescription drug services. The number of samples taken was 100 prescription sheets consisting of 50 compouned drug prescriptions and 50 non-compounded drug prescriptions. Evaluation of research data was carried out by comparing the result of the average waiting time at the community health center with the applicable laws and regulations. The results of research at the Pedan Community Health Center showed an average waiting time for services for compounded drug prescriptions of 19,92 minutes and non- compounded prescriptions of 11,88 minutes. This show that the average waiting time for prescriptions drug services at the Pedan Community Health Center has met the Minimum Service Standards (SPM) in the healt sector in Minister of Healt Regulation No 4 of 2019, namely compounded prescriptions services ≤60 minutes and non-compounded prescriptions ≤30 minutes. Factors that can influence the length of waiting time for prescription drug services are human resource factors (pharmacy pesonel), equipment used, material factors and method factors.

Keywords: Medicine, Community health center, Services, Prescription, Waiting time

FORMULASI SEDIAAN MASKER GEL PEEL-OFF KOMBINASI EKSTRAK DAUN SIRIH (Piper betle L.) DAN MADU (Mel depuratum) SERTA UJI EFEKTIVITAS ANTIBAKTERI TERHADAP BAKTERI Staphylococcus aureus ATCC 25923 DAN Propionibacterium acnes ATCC 6919

Indah Agustianingsih Permatasari Subakti — 2025-06-30

Skin prone to bacterial infections requires special care with antibacterial products. Betel leaf (Piper betle L.) and honey (Mel depuratum) are known for their antibacterial properties. This study aimed to evaluate the physical properties of peel-off gel masks and assess the antibacterial activity of the extracts against Staphylococcus aureus ATCC 25923 and Propionibacterium acnes ATCC 6919. The research used an experimental laboratory method with antibacterial testing through the disc diffusion method. One-Way ANOVA and Tukey HSD post-hoc tests were used to analyze the results.The peel-off gel mask preparations met the required physical standards, with acceptable spreadability, adhesiveness, drying time, and pH. The antibacterial test showed moderate activity, with average inhibition zones of 6.64 mm and 5.71 mm against Staphylococcus aureus, and 8.10 mm and 6.50 mm against Propionibacterium acnes for formulas 1 (20% betel leaf extract) and 3 (10% betel leaf extract and 10% honey). While honey didn’t show antibacterial effects in the mask, it helped maintain skin hydration. The ANOVA results showed a significant difference (p-value < 0.05) in antibacterial activity of the gel masks containing betel leaf extract and honey.

EVALUASI PENGADAAN OBAT DENGAN E-PURCHASING MELALUI E-CATALOGUE DI RUMAH SAKIT UMUM DADI KELUARGA PURWOKERTO

Siti Asadu Sofiah — 2025-06-30

A drug procurement arrangement is made based on the e-purchasing method through e-catalogues to improve the efficiency, effectiveness, and transparency of the drug procurement process for the JKN program. Dadi Keluarga Hospital Purwokerto first used e-catalogues as its procurement method in 2021, which previously used the direct procurement method. In 2023, Dadi Keluarga Hospital Purwokerto did not use the drug procurement method with e-catalogues and returned to using it in 2024, so it is necessary to evaluate drug procurement with e-catalogues at Dadi Keluarga Hospital Purwokerto. This research is a non-experimental qualitative study with a case study that describes the obstacles encountered when procuring drugs through e-catalogues. The results showed several obstacles when implementing drug procurement through e-catalogues, such as the system in the e-catalogue not being optimal, drugs being out of stock by the provider, and the delivery time of goods tending to be long. In addition to these obstacles, procurement with e-catalogues is included in the efficient and effective drug procurement method.

RASIONALITAS PENGGUNAAN ANTIINFLAMASI NON-STEROID (OAINS) PADA RHEUMATOID ARTHRITIS DI RSUD DR. MOEWARDI SURAKARTA TAHUN 2020-2023

Adhi Wardhana Amrullah — 2025-06-30

Rheumatoid arthritis (RA) is an autoimmune disease that attacks the joints with common symptoms such as pain and inflammation of the joints. Pain occurs due to damage to body tissue or potential damage. Complaints of pain in RA are generally treated with non-steroidal anti-inflammatory drugs (NSAIDs). However, the challenge in the use of NSAIDs is the irrational use of drugs. Irrational use of NSAIDs can cause inefficient and ineffective treatment. Therefore, it is necessary to conduct a study of the rationality of the use of NSAIDs in RA patients. This study was conducted to determine the level of rationality at Dr. Moewardi Surakarta Hospital in 2020-2023. The rationality study starts from the correct diagnosis, correct indication of the disease, correct drug, correct dose, correct route of administration and correct interval in non-steroidal anti-inflammatory drugs (NSAIDs) so that they do not cause side effects for patients. This study is a qualitative descriptive observational study using a cross-sectional design. The sample used is retrospective data obtained from patient medical records using a purposive sampling technique. The results of the analysis were carried out on 100 patient medical record data, the data was analyzed for rationality using the 6T method. The results of the analysis were that the correct diagnosis was 100.00%, the correct indication was 100.00%, the correct drug was 85.00%, the correct dose was 100.00%, the correct interval was 100.00%, and the correct route was 96.00%.

FORMULASI KRIM EKSTRAK DAUN KELOR (Moringa oleifera Lam) dan CERAMIDE COMPLEX® SEBAGAI PELEMBAP

Firhani Anggriani Syafrie — 2025-06-30

Moringa leaves are recognized for their high nutritional value and potential use in health and beauty products. Due to their moisturizing, antioxidant, and anti-aging benefits, moringa leaf extract is widely incorporated into skincare formulations. Ceramide Complex plays a key role in strengthening the skin barrier by retaining moisture and preventing dryness. This study aimed to examine the impact of different concentrations of moringa leaf extract on cream formulation characteristics and to assess its moisturizing effectiveness. The methodology involved maceration extraction of moringa leaves, phytochemical screening, cream formulation, and evaluation of its physical attributes. Results indicated that the maceration method successfully extracted 18.6% yield from moringa leaves, which were found to contain alkaloids, flavonoids, saponins, tannins, and steroids. The extract was effectively incorporated into cream formulations, with 3% extract concentration showing optimal moisturizing effects. The final cream passed several evaluation tests, including organoleptic assessment, homogeneity, pH, viscosity, spreadability, adhesion, cycling stability, moisturizing efficacy, irritation testing, and user preference.

UJI TOKSISITAS SUBKRONIK EKSTRAK TERPURIFIKASI DAUN PACAR KUKU (Lawsonia inermis L.) TERHADAP HATI TIKUS

Fitriani W. Alani — 2025-06-30

Pacar Kuku plant (Lawsonia inermis L.) has the main content of active compounds such as flavonoids, glycosides, alkaloids, phenols, essential oils, and glycosides. The most active compounds found in Pacar Kuku leaves are phenols and flavonoids. Pacar Kuku leaves have many pharmacological activities including antimicrobial activity, diabetes mellitus treatment, cytotoxic, antiviral and wound healing effects. The purpose of this study was to determine the subchronic toxicity of purified extract of henna leaves by looking at the histological picture of the liver and symptoms of toxicity in mice. The method of this study was that the experimental animals were divided into 4 groups. The division of treatment groups is as follows: Group 1 as the control group was given Na. CMC 1%, groups 2 to 4 were given purified extract of Pacar Kuku leaves with dose variations of 250 mg / KgBW, 500 mg / KgBW and 1000 mg / KgBW given for 28 days. For 28 days, the animals were observed for toxicity symptoms such as respiratory rate, fatigue, body movement, fur appearance, gait, trembling, saliva production, and urination frequency and histopathological analysis of the heart was performed on the 28th day. Administration of purified extract of Pacar Kuku leaves at doses of 250 mg/kgBW, 500 mg/kgBW and 1000 mg/kgBW did not cause toxicity symptoms but affected the histopathological picture of the liver in mice which was characterized by cell damage in the form of necrosis, fatty degeneration and hydropic degeneration in each treatment group.

FORMULASI SABUN PADAT TRANSPARAN MINYAK JELANTAH DENGAN PENAMBAHAN LIDAH BUAYA (Aloe vera L.)

Umi Nafisah — 2025-06-30

Used cooking oil, which is leftover cooking oil, can be reprocessed into goods or preparations that have added value, one of which is by processing it into solid soap. In soap preparations, additional ingredients are often added, such as aloe vera, because of its antibacterial activity and its properties that can moisturize and soften the skin. The purpose of this study was to determine the formula and physical properties of transparent solid soap, a combination of used cooking oil and coconut oil, with the addition of aloe vera. The study used an experimental method. The soap was made in 6 formulas with variations in used cooking oil: coconut oil (gram) F1 = 0:29; F2 = 29:0; F3 = 6:23; F4 = 12:17; F5 = 17:12; F6 = 23:6. The soap was tested for organoleptic, homogeneity, pH, water content, foam height, free alkali, and unsaponifiable fat. A homogeneous soap preparation was obtained, F1 is yellow, F3, F4, and F5 are orange, and F2 is brownish orange in color, lavender-smelling, and solid in form. pH is following the range of SNI 3532:2016, which is 9 - 11, except for formulas 2 and 4. The height of the foam after being shaken is in the range of 5.2 ± 0.83 - 7.2 ± 0.29, and after being left for 5 minutes, there is a decrease. All formulas meet the requirements for good water content for solid soap preparations, which is less than 15%. The results of the free alkali and free unsaponifiable fat tests show that all formulas have not met the required parameters.

ANALISIS TIGA ASPEK KELENGKAPAN RESEP PADA LAYANAN TELEFARMASI: ADMINISTRATIF, FARMASETIS, DAN KLINIS DI APOTEK JAYA PHARMA 9 KABUPATEN KEDIRI

Anis Akhwan Dhafin — 2025-06-30

Completeness of prescription plays an important role in preventing medication errors that harm patients. This study aims to assess the completeness of prescriptions from administrative, pharmaceutical, and clinical aspects at Jaya Pharma 9 Pharmacy, Kediri Regency, based on the Regulation of the Minister of Health of the Republic of Indonesia No. 73 of 2016. The study was conducted descriptively retrospectively with a population of 224 prescriptions from January-March, then 100 prescription samples were taken that had met the inclusion and exclusion criteria for the period January-March 2025, which were taken using a simple random sampling technique, the data was copied on the Data Collection Sheet. The results showed that in the administrative aspect, the highest completeness was in the patient's name (100%) and the lowest in the prescription unit of origin (70%). In the pharmaceutical aspect, most elements were complete, except for incompatibility (0%). For the clinical aspect, indicators such as indications, doses, and allergies were recorded as complete (100%), while contraindications were not found (0%). In conclusion, there were still incompleteness in several aspects of the prescription, especially administrative and pharmaceutical, which needed to be improved to support standard pharmaceutical services.

FORMULASI DAN EVALUASI SEDIAAN GEL EKSTRAK KULIT BUAH SEMANGKA MERAH (Citrullus lanatus (Thunb.) Matsum & Nakai)

Esti Febri Fatwami — 2025-06-30

Due to its tropical climate, Indonesia is highly susceptible to various types of skin damage, and dry skin problems are widespread. The research aims to investigate the use of white gel extract, a natural ingredient that can be used as a moisturizer, to manufacture gels. The research process begins with sampling, extraction, preparation of moisturizing gel preparations, concentration variations of 3gr, 4gr, and 5gr, as well as preparation evaluation including organoleptic, homogeneity, uniformity, adhesion, pH, and skin moisture testing. The evaluation results showed that the entire formula meets the parameters of good availability. A moisture effectiveness test carried out on the inner arm skin of the panel for five days showed that the skin remained moist before and after use. The humidity values of F+, F0, F1, F2, and F3 are 40.28%, 27.88%, 38.92%, 40.88%, and 42.28%, respectively. Red watermelon peel extract (Citrullus lanatus) in the form of a gel can act as a skin moisturizer and meet good gel standards.

UJI STABILITAS FISIK SEDIAAN EMULGEL MINYAK ATSIRI PALMAROSA (Cymbopogon martinii)

Disa Andriani — 2025-06-30

Topical anti-inflammatory treatment can be administered by formulating Palmarosa essential oil into an emulgel dosage form at concentrations of 2%, 4%, and 6%, which is then tested on rats. In topical preparations, storage conditions greatly affect stability; therefore, stability testing is necessary to determine whether the preparation remains suitable for use. This study aims to evaluate the stability of emulgel formulations containing Palmarosa essential oil. The essential oil was formulated into emulgel preparations at concentrations of 2%, 4%, and 6%. Each of the three formulations underwent physical stability tests, including organoleptic evaluation, spreadability, adhesiveness, pH, and viscosity tests, using the cycling test method for 6 cycles. Based on statistical analysis, all emulgel formulations of Palmarosa essential oil demonstrated good physical stability after the cycling test. Changes in pH, adhesiveness, and spreadability parameters were not statistically significant. Formula 3 was considered the most stable formulation, as changes across all parameters were statistically insignificant and it maintained the most consistent physical characteristics after stability testing.

DETEKSI MOLEKULER DAN DISTRIBUSI PATOGEN RESPIRATORI PADA KASUS INFEKSI SALURAN PERNAPASAN AKUT MENGGUNAKAN PANEL PCR

Yulia Ratna Dewi — 2025-06-30

Infeksi Saluran Pernapasan Akut (ISPA) merupakan masalah kesehatan utama di seluruh dunia, dengan virus sebagai penyebab utamanya. Penelitian ini bertujuan untuk mengidentifikasi distribusi patogen penyebab gejala ISPA menggunakan panel pernapasan PCR dan menganalisis karakteristik demografi pasien yang terkena. Sebanyak 216 pasien dari Rumah Sakit Y di Jakarta didaftarkan antara Januari dan Desember 2023. Klasifikasi patogen mengungkapkan bahwa virus terdeteksi pada 94% kasus, bakteri pada 4%, dan infeksi pada 2%. Mayoritas pasien adalah anak-anak di bawah lima tahun (56%), dan ditemukan hubungan yang signifikan antara jenis patogen dan kelompok usia (p < 0,05), sedangkan tidak ada hubungan yang signifikan yang diamati antara jenis patogen dan jenis kelamin (p > 0,05). Temuan ini menyoroti dominasi infeksi virus pada kasus ISPA, terutama di antara kelompok usia yang lebih muda. Penelitian ini menggarisbawahi pentingnya pernapasan panel PCR dalam memberikan resolusi klinis dan mengurangi penggunaan antibiotik yang tidak perlu. Peningkatan pendidikan kesehatan masyarakat dan tindakan preventif sangat penting untuk mengurangi penyebaran ISPA, terutama di antara populasi yang rentan.

PERAN FAKTOR GENETIK DALAM PERKEMBANGAN KANKER PAYUDARA PADA WANITA USIA 30–60 TAHUN

Yulita Maulani — 2025-06-30

Breast cancer is among the most prevalent cancers in women and a leading cause of mortality worldwide. This study aims to analyze the role of genetic factors in the incidence of breast cancer among women aged 30–60 years. The study employed an analytical observational design with a cross-sectional approach, and participants were selected through purposive sampling. Data were collected from medical records and analyzed using the chi-square test. The results revealed a significant association between genetic factors—particularly a family history of breast cancer—and the occurrence of the disease. Other contributing factors included age at menarche, hormonal contraceptive use, and lifestyle habits. These findings underscore the importance of early detection and awareness of genetic risk factors to improve breast cancer prevention and management strategies.

MODIFIKASI PELARUT DALAM ISOLASI DAN IDENTIFIKASI EUGENOL MINYAK CENGKEH (Oleum caryophyli)

Diyan Sakti Purwanto — 2025-06-30

Clove oil (Oleum caryophyli) is an essential oil obtained from the distillation of clove flower buds. The main components of clove oil are terpenes and their derivatives. The main terpenes of clove oil are eugenol (60-90%), eugenol acetate, and caryophyllene. Eugenol has a refreshing and spicy aroma so it can be a component to freshen the mouth. In this study, the solvent modification between ethanol and ether was carried out in identifying and isolating clove oil eugenol. The results of organoleptic observations on ethanol solvents showed a dark yellow solution color while on diethyl ether it was clearer. Eugenol is a colorless, odorless, hard liquid with a spicy taste. Eugenol will easily turn brown when in open conditions. In the isolation process, diethyl ether is better at isolating eugenol. The yield obtained in the isolation process was 39.3%. From the TLC test, the Rf value 0.8 was obtained where the longer the spots, the greater the Rf value on the TLC plate, which means that more compounds are attracted. The results of the isolation and identification of eugenol show that diethyl ether solvent is more effective in the process of isolating clove oil eugenol.

PATIENT SATISFACTION STUDY TOWARDS COMPLAINT HANDLING RESPONSIBILITY IN INPATIENT SERVICES AT HOSPITAL “X”

Dewi Weni Sari — 2025-06-30

Abstrak

Kepuasan pasien merupakan point penting dalam menilai mutu layanan di rumah sakit. Responsivitas rumah sakit dalam menangani komplain pasien sangat mempengaruhi kepuasan. Tujuan dalam penelitian ini untuk mengetahui kepuasan pasien terhadap responsivitas penanganan komplain di layanan rawat inap rumah sakit ‘X”. Penelitian ini menggunakan metode deskriptif kuantitatif dengan menyebarkan kuisioner kepada 100 pasien rawat inap yang pernah menyampaikan komplain selama perawatan dan melakukan wawancara kepada kepala bagian penanganan komplain di rumah sakit. Analisis data menggunakan rumus CIS untuk melihat persentasi kepuasan pasien terhadap penanganan komplain yang diberikan oleh petugas di rumah sakit dan studi pustaka. Hasil penelitian menunjukan bahwa secara keseluruhan tingkat kepuasan pasien rawat inap terhadap responsivitas penanganan komplain di rumah sakit mendapatkan nilai sebesar 93,79%. Dari wawanacara yang dilakukan penanganan komplain di rumah sakit sudah terstruktur menggunakan SOP sebagai pedomannya, penyampaian komplain bisa secara langsung atau lisan (disampaikan ke perawat secara langsung atau via telpon) dan tidak langsung (kotak saran, email dan media sosial rumah sakit).

PENGARUH VARIASI KONSENTRASI ASAM STEARAT DAN TRIETANOLAMIN TERHADAP EVALUASI FISIK SEDIAAN LOTION EKSTRAK DAUN STROBERI (Fragaria x ananassa var Duchesne)

Vania Santika Putri — 2025-06-30

Strawberry leaves contain flavonoid, tannin, and saponin compounds that have the potential as ultra protection sunscreen with an SPF value of 52.90. Therefore, strawberry leaves have the potential to be used as active ingredients in sunscreen in the manufacture of lotion formulations. This study aims to determine the formulation and physical evaluation and the effect of variations in emulsifier concentration on the physical properties of strawberry leaf extract lotion preparations (Fragaria x ananassa var duchesne). The manufacture of strawberry leaf extract uses the maceration method with 96% ethanol solvent with a ratio of simplicia and solvent of 1:10. Lotion is made by varying the concentration of triethanolamine and stearic acid F1 (2%: 10%), F2 (3%: 11%), and F3 (4%: 12.5%). The physical evaluation carried out includes organoleptic tests, homogeneity, pH, spreadability, adhesion, viscosity, lotion type and hedonic. The results of the homogeneity and homogeneity tests of the three formulas showed that homogeneous preparations had the same color, odor, and texture. All lotion test results have met the requirements with pH in the range of 5.30±0.03 - 5.44±0.04; spreadability 5.28±0.098 - 6.35±0.360 cm; adhesion 6.23±0.394 - 10.29±0.443 seconds; viscosity 3914.1±0.91 - 3914.8±0.50 cps. Variations in the concentration of stearic acid and triethanolamine significantly affect the pH test, spreadability, adhesion and do not significantly affect the viscosity test.

ANALISIS INTERAKSI OBAT PADA PASIEN COVID-19 DENGAN PENYAKIT ASMA DI INSTALASI RAWAT INAP RSD GUNUNG JATI

trisna lestari — 2025-06-30

Covid-19 with treatment of asthma must be considered. Because comorbid patients experience polypharmacy, this study aims to determine patient profiles, drug interactions based on mechanism,severity and significance of the use of Covid-19 drugs with asthma comorbidities at the inpatient installation of RSD Gunung Jati Cirebon.This study is a non eksperimental study with retrospective data collection, namely medical record data of patients with confirmed Covid-19 with comorbid asthma. Sampling using total sampling technique as many as 51 medical records. The study was conducted from November 2022 ti July 2023. Determination of drug interactions using the drugs.com application. Descriptive statistical data analysis in the form of percentages and tables. Based on the result of a study of Covid-19 patients with comorbid asthma, the age group was dominated by the group of 46-55 years (31%) and the gender of 32 patients (62%) was female. There were 14 potential drug interaction events from 51 patienst with a pharmacodynamic mechanism of action in 31 cases (91,18%) and pharmacokinetics in 3 cases (8,82%). Based on the level of severity, namely 7 cases (20,59%) for major interactions, 21 cases (61,76%) for moderate, 6 cases (17,65%) for minor. Covid-19 drug interactions with asthma comorbidities are mostly pharmacodynamic mechanism and moderate in severity.