POTENSI INTERAKSI FARMAKOKINETIK OBAT STATIN PADA PASIEN RAWAT INAP: KAJIAN RETROSPEKTIF DI RUMAH SAKIT X PALEMBANG

Abstract

Drug interaction is defined as an alteration in the effect of a drug caused by the administration of another drug, either given previously or concurrently, which may influence the effectiveness or increase the toxicity of one or more drugs. This study was conducted to analyze the potential drug interactions associated with statin therapy among hospitalized patients at Hospital X in Palembang during the period of January–December 2023. This study uses retrospective data with descriptive analytical research design. Based on the calculation using the Slovin formula, 76 medical records were used as the sample. The results show that the highest patient age group was 56–65 years (36%), the majority were female (64%), and the most common diagnosis was hypertension (26%). The most widely used statin was simvastatin (55%), followed by atorvastatin (45%). The most commonly co-prescribed drug class was antihypertensives (29%). Drug interaction potential was found in 83% of patients, while 17% had no potential interactions. The predominant severity level was moderate (52%), followed by major (47%), and minor (1%). The most common interaction mechanism was pharmacokinetic (91%), followed by pharmacodynamic (9%).